This document provides guidance around best practices for cleaning, disinfecting and caring for the polyurethane covers for assistive products for tissue integrity when lying down (APTIs) where the covers are designed to protect the internal components of the APTI from damage. Adherence to this guidance will extend the operational life of the APTI and its tissue integrity performance. This document gives guidance for cleaning and disinfecting by manual means only. This document is not intended to give guidance related to the efficacy of the cleaning and disinfection procedures.